The cause of the crash is unknown and will be investigated, the statement said.
The Marines were flying in support of Exercise Predator’s Run, a joint military exercise involving troops from Australia, the United States, and other countries, the force added.
Australian Prime Minister Anthony Albanese called the crash “tragic,” Reuters reported.
Northern Territory Chief Minister Natasha Fyles said Sunday that the aircraft crashed in a remote area and no civilians were injured. She said an emergency response was underway to triage the victims of the crash and transport them to hospital.
“Australia and the U.S. are working together to respond to this incident,” she said.
Five Marines killed in Osprey crash in California desert
The police commissioner for the Northern Territory, Michael Murphy, said Melville Island has a long history of serving as a base for military exercises, and an emergency response was activated almost immediately.
The U.S. Marine Corps did not immediately respond to a request for comment early Sunday.